NEFL and Schnyder corneal dystrophy: Cross-sectional plasma p181 levels were elevated in A + SCD compared to A + CU (1.7 ± 0.1 vs 1.3 ± 0.1 pg/mL; p = 0.009) and to A-SCD (1.1 ± 0.0 pg/mL; p < 0.001) (Fig. 1A), while there was no difference of A + SCD compared to A + MCI (1.9 ± 0.1 pg/mL; p = 0.453) (for comparison to CSF p181 levels, see Supplement 1).Plasma NfL levels were increased in A + SCD compared to A-SCD (17.7 ± 1.3 vs 14.3 ± 0.6 pg/mL; p = 0.022).