In human myeloma cells, Ikaros zinc finger 1 (IKZF1) was identified as the pivotal transcriptional activator of SLAMF7 [54]; however, the murine SLAMF7 (mSLAMF7) promoter was found to be regulated by YY1 in B cells [55]. The gene discussed is YY1; the disease is plasma cell myeloma.