The ICC additionally recognizes BCL11B-activated ETP-ALL, and not otherwise specified (NOS) T-ALL along with 8 provisional entities, several of which are discussed in this review (TAL1/2-rearranged (TAL1/2r), TLX1r, TLX3r, HOXA, LMO1/2r, NKX2r, SPI1r, basic helix loop helix) [5]. The gene discussed is BCL11B; the disease is acute lymphoblastic leukemia.