Cheng et al. determined homoharringtonine as an anti-STAT3 agent by regulating the crosstalk between STAT3 and Wnt signaling to achieve preventing CRC progression and recurrence.463 Homoharringtonine remarkably inhibited STAT3 expression and reduced epidermal growth factor-mediated β-catenin expression, leading to the inhibition of Wnt signaling to breakdown cancer stem-like tumorspheres in selective EGFR-positive CRC. The gene discussed is STAT3; the disease is cancer.