MiR-17-5p can directly bind to the 3’ UTR of JAK1 and STAT3, and block the expressions of JAK1, p-STAT3, and STAT3, thus provide supporting evidence for berberine to prevent the progression of bladder cancer.205 Homoharringtonine can prevent cells growth, cell viability, and induce cell apoptosis through mitochondria pathway in gefitinib-resistant NSCLC cell lines.405 Mechanistically, homoharringtonine retards IL-6-induced STAT3 tyrosine 705 phosphorylation and deactivates JAK1/STAT3 signaling.405 Wherein, cells with EGFR T790M mutation are more sensitive to homoharringtonine treatment. Here, JAK1 is linked to urinary bladder cancer.