In addition, due to its unique estrogenic properties, genistein can disrupt estrogen binding within molecules and affect estrogen-dependent pathways in a dose-dependent manner,127,128 It can effectively inhibit the development of breast cancer by blocking estrogen and inhibiting tumor cell proliferation, because it has a strong affinity for ERβ than ERα.129 The above preclinical studies collectively support the role of genistein in preventing, retarding, and blocking cancer development, indicating genistein is a promising chemopreventive drug. Here, ESR1 is linked to cancer.