STAT3 and colitis: Curcumin might be a chemoprevention agent for CRC, as it can suppress the activation of dendritic cells by diminishing the phosphorylation of JAK2, STAT3, and STAT6, elevating the downstream proteins of suppressor of cytokine signaling (SOCS) 1, SOCS3, and protein inhibitor of activated STAT3 to restore immunologic balance and to treat colitis in an effective manner.396 Curcumin can inhibit the growth and recurrence of various tumors by adjusting JAK/STAT signaling pathway.