HNF4A and colorectal carcinoma: Berberine can also downregulate lincROR, inducing the inactivation of Wnt/β-catenin signaling in vitro and in vivo and leading to the CRC cell cycle arrest and apoptosis.340 Piperine inhibits the translocation of β-catenin to the nucleus and might suppress the binding of TCF/LEF to the DNA, thus suppresses Wnt/β–catenin pathway to show an anti-CRC effect.341