Berberine inhibits JAK2/STAT3 pathway through reducing the expression of IL-6, thereby causing G0/G1 phase cell arrest and apoptosis in gastric cancer cell in vitro and in vivo.404 Through upregulation of miR-17-5p, berberine exhibits anti-bladder cancer effect via inactivating JAK1/STAT3 signaling. The gene discussed is JAK1; the disease is urinary bladder cancer.