NRP1 and glioma: When curcumin was encapsulated into milk-derived EVs, it was shown enhanced antiproliferative activity against multiple cancer cell lines, especially enhanced higher antitumor activity in cervical tumor xenograft model.586 Jia et al. loaded superparamagnetic iron oxide nanoparticles (SPIONs) and curcumin into exosomes and then conjugated the exosome membrane with neuropilin-1-targeted SC peptide to obtain glioma-targeting exosomes.587 These exosomes provided good results for the synergistic anti-glioma effect with SPION-mediated magnetic flow hyperthermia and curcumin-mediated therapy.