NFE2L2 and cancer: Given that previous researches have comprehensively reviewed oxidative stress and antioxidant defense celluar signaling molecules as targets, such as nuclear factor erythroid 2-related factor 2 (Nrf-2)/antioxidant response element (ARE) pathway,22,253,254 activator protein 1,17 matrix metalloproteinases (MMP)255 of the role in cancer chemoprevetion, and we will not go into much detail here.