NPCs regulate gene expression by actively participating in the selective import of transcription factors, as well as chromatin remodeling and histone modification.22 NUP62, located in the central avenue of NPC, plays a vital role in regulating selective transport between the nucleus and cytoplasm.21 Researchers have conducted extensive screenings to identify Nups associated with the pathogenesis of Huntington’s disease. The gene discussed is NUP62; the disease is Huntington disease.