NUP62, a phenylalanine-glycine nucleoporin (FG-Nup), plays a critical role in regulating selective nucleocytoplasmic transport.21,28,33 Impaired nucleocytoplasmic transport is a key feature of aging and neurodegenerative diseases.19,21,32,34 Notably, our data revealed a significant interaction between the overexpression of NUP62 and E2F signaling activity. This evidence concerns the gene NUP62 and neurodegenerative disease.