RNASE1 and lung carcinoma: In both EPHA4 wild-type or EPHA4 knockout lung cancer cells, RNase1 could bind to ALK (Supplementary Fig. 1, c) and ALK did not bind to EPHA4 (Supplementary Fig. 1, d), which suggested that the RNase1-ALK interaction was independent of EPHA4 in lung cancer cells.