Consistently, only RNase1, but not the others, induced ALK phosphorylation at Y1604 (Fig. 1b), an indicator of ALK activation.32 This is consistent to recent report indicating that ALK can be activated by RNase1.20 We then examined RNase1 expression and ALK activation in 13 lung cancer cell lines and an immortalized human bronchial cell line HBE4-E6E7. The gene discussed is RNASE1; the disease is lung cancer.