Poojitha et al. showed that DMF enhances mitophagy, contributing to the prevention and treatment of Parkinson’s disease via the NRF2/BNIP3/PINK1 pathway.34 Pink1 knockout mice exhibited lower BV/TV combined with trabecular thickness and more osteoclasts than wild-type mice upon ligature placement.56 Therefore, maintaining mitochondrial homeostasis by promoting mitophagy may be an important therapeutic strategy for preventing and treating periodontitis. This evidence concerns the gene BNIP3 and periodontitis.