A recent study has shown that TUFM regulates mitophagy to alleviate the progression of nonalcoholic steatohepatitis by removing damaged mitochondria.29 Given the regulation and function of TUFM and the biological role of DMF, we suggest that DMF alleviates mitochondrial dysfunction and oxidative damage through TUFM-mediated mitophagy. The gene discussed is TUFM; the disease is metabolic dysfunction-associated steatohepatitis.