Poojitha et al. showed that DMF enhances mitophagy, contributing to the prevention and treatment of Parkinson’s disease via the NRF2/BNIP3/PINK1 pathway.34 Pink1 knockout mice exhibited lower BV/TV combined with trabecular thickness and more osteoclasts than wild-type mice upon ligature placement.56 Therefore, maintaining mitochondrial homeostasis by promoting mitophagy may be an important therapeutic strategy for preventing and treating periodontitis. Here, PINK1 is linked to periodontitis.