As an important DUB, USP9X regulates multi-types of cancer development, such as glioblastoma, lung cancer, colorectal cancer, and breast cancer, through mediating the stability of ALDH1A3, KDM4C, FBW7, CEP131, and Snail1 [24, 31–34]. Here, ALDH1A3 is linked to colorectal cancer.