A proteogenomic study on clinical cancer demonstrated that lysine-specific demethylase 1 (LSD1), encoded by KDM1A gene, is critical in Lung Squamous Cell Carcinoma (LSCC) and head and neck cancer and shares tissue and cell type of origin.11 LSD1 controls SOX2 expression and is currently being investigated in a clinical context in conjunction with immunotherapy to reduce SOX2 expression in LSCC (NCT04350463). Here, SOX2 is linked to head and neck cancer.