STAT3 and neoplasm: Although STAT3 is an attractive target, it is difficult to target OSCC cells because of its various modes of regulation.20,21 The interaction between EGFR and STAT3 promotes malignancy.22 This study aimed to evaluate how LSD1 initiates preneoplastic changes by activating early events such as STAT3 signaling, cell cycle mediators, and tumor immunity, which are useful for understanding progressive OSCC lesions from precancer and therapeutic intervention.