Interestingly, we evaluated the detailed mechanism by which LSD1 inhibition regulates the phosphorylation of CDK7 during HNSCC progression and LSD1 regulates STAT3 and CDK7 by regulating the methylation status of H3K4 and H3K9, which are unique findings demonstrating the specific role of LSD1 in HNSCC. This evidence concerns the gene KDM1A and head and neck squamous cell carcinoma.