Moreover, suppression of FAO by etomoxir clearly abolished the proliferation of GC cells promoted by upregulation of SLC25A42 (Fig. 6H, I), while rescued the ferroptosis of GC cells suppressed by upregulation of SLC25A42 (Fig. 6J), suggesting that SLC25A42 promotes GC cell proliferation and inhibit ferroptosis by activating FAO mainly through reducing energy production and ROS-mediated lipid peroxidation. The gene discussed is SLC25A42; the disease is gastric cancer.