Notably, among patients with NT-proBNP >10,000 pg/L, those with CFS 8 or 9 had the worst prognosis, with a median survival of 0.2 year (Q1-Q3: 0.1-0.8 year) (Figure 4A, Supplemental Figure 3A). This evidence concerns the gene NPPB and myalgic encephalomeyelitis/chronic fatigue syndrome.