SAMe has multiple pharmacologic actions: (1) hepatoprotective but proapoptotic in liver cancer31 and colon cancer cells,32 (2) prevent vascular endothelial cell dysfunction,17 (3) inhibit liver fibrosis,18 (4) inhibit release of proinflammatory cytokines by activated KCs,20 and (5) inhibit CRLM in a mouse model.33 Here, TBCE is linked to Hepatic fibrosis.