SERPINE1 and steatosis: ,43,44 Elevated plasma levels and hepatic expression of PAI-1 correlate with degree of liver fibrosis and steatosis, whereas PAI-1 deletion or inhibition can ameliorate liver fibrosis and block high-fat diet-induced metabolic-dysfunction-associated steatotic liver disease.45, 46, 47 Supporting a causative role of PAI-1, PAI-1 KO mice are protected from FOLFOX-induced SOS.