Moreover, NAT10-mediated ac4C modification facilitates the progression of other kinds of cancer, such as gastric cancer, bladder cancer, and cervical cancer.33, 34, 35 Besides, the authors also found that NAT10 inhibition improved T-cell activation and suppressed immune escape induced by kynurenine, suggesting that kynurenine suppressed immune function and facilitated immune escape via promoting the expression of NAT10. The gene discussed is NAT10; the disease is urinary bladder cancer.