Compared with normal lesions, lipid ROS and ferrous iron, the expression of acyl-CoA synthetase long-chain family member 4 (ACSL4) were increased, and the expression of GPX4 was decreased in psoriatic lesions, Fer-1 significantly suppresses ferroptosis and alleviates psoriasiform dermatitis [6,7]. The gene discussed is ACSL4; the disease is Psoriasiform dermatitis.