ABO and hemorrhage: This alloimmunization can occur through non-immunological mechanisms such as sepsis, fever, disseminated intravascular coagulation, drugs (amphotericin-B), hypersplenism, platelet consumption by hemorrhage, or by immunological mechanisms of HLA alloantibodies, ABO alloantibodies, platelet-specific alloantibodies, as well as autoantibodies.38