Mechanistically, increased AMPK signalling can inhibit β-AR pathway activation, thereby blocking cardiac remodelling and inflammasome activation [54]; (3) microtubule affinity-regulating kinase 4 (MARK4), a member of the AMPK-related kinase family, is upregulated in myocardial infarction [34] and diabetic cardiomyopathy [55]. The gene discussed is MARK4; the disease is diabetic cardiomyopathy.