Consistent with our previous findings, the marker genes of the tumor‐representing cluster 1 are enriched in Sema4D‐related pathways, which are associated with breast cancer metastasis.[43] Similarly, the marker genes of the TME‐representing cluster 2 are enriched in immune‐related RHO GTPase GO terms, which have recently been shown to have tumor suppressor functions.[44] Furthermore, the adipose tissue‐representing cluster 2_2 is enriched in a GO term associated with adipocyte differentiation (R‐HSA‐381 340, adjusted p ⩽ 0.0001). Here, SEMA4D is linked to breast cancer.