ERBB2 and neoplasm: Furthermore, we wish to examine the possible biological insights revealed by CeiTEA hierarchical clusters, for which we considered two datasets from cancerous tissues: a HER2‐positive breast cancer (BC) dataset comprising eight samples[42] and a pancreatic ductal adenocarcinoma (PDAC) dataset consisting of one sample.[18] Here, we demonstrate the robustness of CeiTEA in delineating tumor and tumor microenvironment (TME) regions, identifying subregions at the tumor‐TME boundary, and characterizing heterogeneity within both tumor and TME regions.