Alzheimer's disease (AD), the most prevalent type of dementia in older adults,[1] is characterized by a biological process that begins with AD neuropathologic changes (ADNPC).[2] The accumulation of amyloid‐β plaques is a molecular hallmark of AD,[3] occurring earlier than other ADNPCs, such as Tau‐mediated neuronal injury,[4] and playing a critical role in disrupting neuronal function and contributing to neurodegeneration. Here, MAPT is linked to Alzheimer disease.