The modified cationic antimicrobial peptides KT2 and RT2 derived from Crocodylus siamensis Leucrocin I exhibited anticancer activity against human colon cancer HCT-116 cells, in which RT2 peptide upregulated proteins, including CFTR, Wnt7a, TIA1, PADI2, NRBP2, GADL1, LZIC, TLR6, and GPR37, within the tumor, resulting in suppressed tumor growth in mice [25–27]. This evidence concerns the gene PADI2 and neoplasm.