In addition to the benefits of the newer medications for reducing severe hypoglycemia, as well as cardiovascular and renal morbidity and mortality, our study also accounted for the potential side effects associated with GLP-1 receptor agonists and SGLT-2 inhibitors, such as gastrointestinal issues, pancreatitis, urogenital infections, and ketoacidosis. The gene discussed is GLP1R; the disease is Hypoglycemia.