Preclinical and clinical evidence suggested that the potential immunostimulatory mechanism of radiation includes6, 7, 8, 9 mediating cell death caused by DNA damage by stimulating the simulator of interferon genes‐nuclear factor kappa B (STING‐NFκB) signaling pathway, upregulating expression of major histocompatibility complex class‐I (MHC‐I), increasing expression of antigens and activating antigen‐presenting cells, which migrated to tumor‐draining lymph nodes (TDLNs) and then priming cytotoxic T lymphocytes, remodeling the tumor microenvironment, etc. The gene discussed is NFKB1; the disease is neoplasm.