CD8A and neoplasm: Greater fold-change increases in endogenous CD4+ T cell accumulation in bone marrow were observed compared with CD8+ T cells, in keeping with previous descriptions of tumor-induced CD4+ T cell sequestration (endogenous CD4+ fold-change of 2.69× versus CD8+ T cells fold change of 1.76× at 72-hour observation point) (5, 32, 33).