AZD1390 effectively inhibited ATM, as indicated by significantly reduced phosphorylated KAP1 (p-KAP1) expression in the treated group when compared with expression levels in the control group (P = 0.01, Mann-Whitney U test) and increased GH2AX expression (P = 0.03, Mann-Whitney U test) in tumor-bearing mice (Figure 4, C–F). This evidence concerns the gene ATM and neoplasm.