Since adipose tissue macrophage (ATM) accumulation plays important role in contributing to insulin resistance and obesity (Xu et al., 2003; Lumeng et al., 2007), we investigate whether STF treatment impacts ATM accumulation in DIO mice as IRE1α activity was observed to be heightened in obese macrophages (Shan et al., 2017). Here, ERN1 is linked to Obesity.