However, the mRNA levels of individual Tnfa, Il1b, or Ccl2 are differentially expressed among CD9+CD11c-, CD9-CD11c+, and CD9+CD11c+ ATMs (Figure 7H), suggesting functional heterogeneity even among proinflammatory ATMs during obesity. The gene discussed is ITGAX; the disease is obesity due to melanocortin 4 receptor deficiency.