The IRE1α deletion was reported to achieve this by reversing the obesity-induced M1/M2 polarization (Shan et al., 2017), leading to the augmented M2 population in adipose tissue that induces BAT activation and WAT remodeling through the synthesis and action of catecholamines (Nguyen et al., 2011; Shan et al., 2017). The gene discussed is ERN1; the disease is obesity due to melanocortin 4 receptor deficiency.