When particlized IFN-γ were combined with radiation, no significant increase was observed with 10-Gy irradiation (Fig. 4D, F, , , c) but a significant increase was observed with 20-Gy irradiation (Fig. 4D, F, , , e), in both primary tumor (Fig. 4E) and pulmonary metastases (Fig.-4 G). Here, IFNG is linked to neoplasm.