The Genome-Wide-Association Study (GWAS) identified 17 MASLD-associated genes, such as torsin family 1 member B (TOR1B), fat mass and obesity-associated (FTO) gene, growth factor receptor-bound protein 14 (GRB14), insulin receptor (INSR), cordon-bleu WH2 repeat protein like 1 (COBLL1), sterol regulatory element-binding transcription factor 1 (SREBF1), and patatin-like phospholipase domain-containing protein 2 (PNPLA2) [22]. This evidence concerns the gene PNPLA2 and obesity due to melanocortin 4 receptor deficiency.