ZEB1 and neoplasm: Expression analysis of levels of a second set of miRs, miR-199a and miR-145, exhibited consistent upregulation in tissue but downregulation in plasma, suggesting their robust tumor-suppressive roles as they are involved in inhibiting epithelial–mesenchymal transition (EMT) and metastasis by targeting key transcription factors such as ZEB1 and TWIST1 (twist-related protein 1) [97,98].