DROSHA and 22q11.2 deletion syndrome: The hairpin structures undergo lariat debranching by the debranching enzyme 1 (DBR1), subsequently cleaved by the RNase III enzyme DROSHA, which forms a microprocessor complex with RNA-binding protein (RBP), the DiGeorge syndrome chromosome region 8 (DGCR8), thereby leaving the debranched intron to form a hairpin structure that resembles a pre-miRNA [48].