As expected, pathologies typical of ADD, PSP and LB pathology were significantly different between groups, with ADD having the highest densities of amyloid plaques and neurofibrillary tangles, PSP the highest level of pathological tau (summation of neuronal and glia tau scores) and PD with the highest densities of alpha-synuclein pathology (Table 1). The gene discussed is MAPT; the disease is Parkinson disease.