CLN3 and early-onset autosomal dominant Alzheimer disease: If the temporally agitation-related autonomic imbalance demonstrated in CLN3 adolescents and adult war veterans proves to be reproducible in a larger cohort of patients with AD and/or other types of dementia, it has the potential to be a paradigm shift in how we understand and prevent and treat agitation in advanced stages of dementia, including Alzheimer’s disease.