MKI67 and glioblastoma: When we divided the glioblastoma samples into two groups based on Ki-67 index (≤50% (low) and >50% (high)), significantly higher methylation levels were observed at CpG 03 in intergenic enhancer A (p = 0.023) in samples with high Ki-67 index compared to those with low Ki-67 index (Figure 7D).