In MGMT promoter methylated glioblastoma samples, significant differences were found for CpGs in intergenic enhancers B and E, as well as intragenic enhancer I. In promoter unmethylated samples with TERT SNP mutation, significantly higher methylation levels were observed for intergenic enhancers B, D, and E compared to samples with the TERT SNP wildtype. Here, MGMT is linked to glioblastoma.