When looking at the nominal significance level, major differences were found when comparing AD APOE ε4 carriers and control APOE ε4 non-carriers, represented by 980 DMPs (absolute β difference ≥ 0.1 and p-value ≤ 0.05) annotated to 668 genes (Supplementary Materials: Table S4). Here, APOE is linked to Alzheimer disease.