When stratifying by APOE ε4, we identified 17 DMRs (12% hypermethylated and 88% hypomethylated) comparing AD APOE ε4 carriers and control APOE ε4 non-carriers and 4 hypermethylated DMRs between AD APOE ε4 non-carriers and control APOE ε4 non-carriers (Sidak correction p-value < 0.05) (Table 5 and Table 6). The gene discussed is APOE; the disease is Alzheimer disease.