Moreover, through immunoblot analysis, it was found that the interaction between ALDH1A3, the aldehyde dehydrogenase isoform, and PKM2 promotes the production of lactate in GBM cells, which in turn leads to lactylation of XRCC1 at the K247 locus, a scaffolding protein to repair DNA, regulating the cellular localization of transcription factors and the ability of XRCC1 to bind to DNA. The gene discussed is XRCC1; the disease is glioblastoma.