RHOA and periodontal disorder: Significant terms included processes known to be involved in the differentiation of ameloblasts and odontoblasts like the RhoA and Rac1 GTPase cycles [32], as well as calcium ion binding, which is crucial for proper enamel mineralization, and the Hippo pathway, which is essential for teeth development and morphogenesis [33] and also plays a critical role in endodontics, orthodontics, and periodontal diseases [34].