LRRTM1 and dental caries: The fourth most hyper-methylated region in the MIH sample, located on chr2:80,000,000–81,000,000 (p12), hosts CTNNA2, a gene constitutively expressed in normal oral mucosa [26] which was found to be differentially expressed in murine ameloblasts [27], and LRRTM1, which was associated with dental caries in human adults [28].