SOD1 and glomerulosclerosis: In animal models, EC-SOD knockout mice showed attenuated renal blood flow and decreased SOD activity after kidney ischemia/reperfusion [127], while Rodríguez-Iturbe et al. showed that SOD2 deficiency was associated with renal interstitial inflammation and accelerated glomerulosclerosis, tubulointerstitial damage and salt-sensitive HT, especially in aged mice [128].