In collaboration with the Swiss IBD Cohort (SIBDC) and the City of Hope Translational Biomarker Discovery Core Facility, we performed a proteomics screen on serum samples from IBD patients genotyped with the IBD-associated loss-of-function (LOF) rs1893217 SNP in PTPN2 [14,15,16]. Here, PTPN2 is linked to inflammatory bowel disease.