Maimaiti et al.’s bioinformatics study [48] linked DNA methyltransferase 3 alpha (DNMT3A) to lower SAH and unruptured intracranial aneurysm (UIA) risks, whereas methyl-CpG-binding domain protein 2 (MBD2) was linked to higher UIA risks, highlighting the role that DNA methylation plays in the pathogenesis of IA. This evidence concerns the gene MBD2 and Dilatation of the cerebral artery.