TNF-α plays a different role in obesity, and it can cause an increase in a person’s glucose resistance and obesity/T2DM, a change in adipogenesis, and lipolysis, thus increasing other cytokines production (such as MCP-1, IL-6) which, in turn, will aggravate systemic inflammation [28]. This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.