Similar changes in the phospholipid profile, accompanied by protection against HFD-induced obesity and hepatic steatosis, have also been observed in mice deficient in the Ca2+-independent PLA2 group VIA (iPLA2β, also known as PLA2G6 or PNPLA9) [87] or group VIB (iPLA2g or PNPLA8) [88,89], suggesting the importance of the proper phospholipid/lysophospholipid ratio for hepatic homeostasis [21]. Here, PNPLA8 is linked to fatty liver disease.