IGHE and asthma: Additionally, CBD demonstrated the potential to decrease the levels of TNF-α, the major mediator of severe asthma, IL-6, a cytokine stimulating T cell proliferation, and IL-13, involved in every aspect of asthma pathophysiology, such as IgE production, eosinophil recruitment, maturation of mucus-secreting goblet cells, and enhanced airway smooth muscle contractility [85,87].