AIRE and autoimmune disease: Aire in mTECs has been demonstrated to control the expression of self-antigens, and a deficiency of Aire results in the development of organ-specific autoimmune diseases due, at least in part, to a defect in the expression of tissue-restricted self-antigens (TRAs) (Březina et al., 2022; Abramson et al., 2010; Anderson et al., 2002).