A 2021 study on a new linker system found that its MMAF-conjugated ADCs, called LegoChem Bisciences-ADC (LCB-ADC), displayed higher cytotoxicity than T-DM1 by noticeably inhibiting tumor growth in a HER2-high-expressing N87 xenograft tumor [95]. This evidence concerns the gene ERBB2 and neoplasm.