For example, we found that when P53 is set to 0, upregulating PTEN while downregulating Akt could reduce the tumor attractor domain to 6.47%, which is about 22.84% of the attractor size in the no intervention group (28.32%) or 13.36% of the size in the P53 mutation group (48.40%), and this result comes from a random exploration covering only 2.7% of the total combination space. The gene discussed is AKT1; the disease is neoplasm.