RPS6KB1 and cancer: For example, in various types of cancer (e.g., hepatocellular carcinoma, breast cancer, neuroblastoma, and prostate cancer), activation of mTOR/S6K signalling by CaMKIV results in translocation of S6K into the nucleus where it interacts with RORγt to cause transcriptional activation of IL-17-producing Th17 cells [76].