In AOM/DSS-induced and T-bet−/−, Rag2−/− CAC models, IL-6, CCL2, G-CSF, and GM-CSF (encoded by Csf2) fostered MDSC accumulation in evolving colonic tumors and boosted T cell suppression by MDSCs in a STAT-dependent manner [100,101,102]. The gene discussed is CSF2; the disease is infectious otitis media.