Zigmond, et al. further uncovered the differentiation of Ly6Chi monocytes with time in murine IBD: grafted Ly6Chi monocytes differentiated into CX3CR1-GFPintLy6ChiF4/80loCD11c− cells 1 day after adoptive transfer into DSS-challenged mice, then, by 3 days after, they became antigen-presenting CX3CR1-GFPintLy6CloF4/80lo cells with high expression of MHCII and CD11c [20]. Here, CX3CR1 is linked to inflammatory bowel disease.