It was shown that the inhibition of enhancer of zest homolog 2 (Ezh2), a major histone methyltransferase, promoted the differentiation of hematopoietic progenitor cells (HPCs) into MDSCs by activating the Janus kinase (JAK)-STAT and TNF signaling pathways in DSS-induced colitis [33]. The gene discussed is EZH2; the disease is colitis.