Based on these premises, the aim of the current study was to examine whether the vascular phenotype (i.e., aortic stiffness and carotid intima-media thickness) of patients with MASLD differed between carriers and noncarriers of the PNPLA3 polymorphism, rs738409[G] allele. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.