Mutations in genes such as ten-eleven translocation-2 (TET2), Janus kinase 2 (JAK2), and DNA methyltransferase 3 alpha (DNMT3A), which are frequently observed in patients with CH, have been shown to promote inflammatory responses and alter macrophage function in the context of atherosclerosis [18,19,20]. This evidence concerns the gene DNMT3A and cyclic hematopoiesis.