This is particularly relevant given that AKR1B10 overexpression has been implicated in breast cancer cell adhesion, migration, and invasion via the integrin α5-mediated focal adhesion signaling pathway, a pathway that involves Rac1 [47], that was previously identified as a downstream signaling partner of AQP5, and that contributes to cell migration [48]. Here, AKR1B10 is linked to breast cancer.