In HT-29 colon cancer cells, AQP5 has been shown to contribute to resistance to 5-fluorouracil and cisplatin, as silencing of AQP5 suppressed multidrug-resistance (MDR) genes through inhibition of the p38 mitogen-activated protein kinase (MAPK) pathway [27]. The gene discussed is AQP5; the disease is malignant colon neoplasm.