AQP5 drives breast cancer progression by downregulating the polarity protein Scribble and activating Ras and WNT (Wingless-related integration site)/β-catenin signaling, leading to disrupted cell polarity, enhanced proliferation, epithelial–mesenchymal transition (EMT), and cancer-cell dissemination [23,24]. The gene discussed is AQP5; the disease is breast carcinoma.