NFE2L2 and cancer: Further, we exposed AQP5-overexpressing cells, cells transfected with the empty vector, and control cells from each breast cancer cell line to H2O2 for 24 h and evaluated their viability, intracellular ROS levels, and the involvement of major signaling pathways related to the antioxidative response and cancer progression (NRF2, PI3K/AKT, and FOXO pathways).