Furthermore, the biochemical and behavioral characteristics of alpl-/- zebrafish described in the present study were comparable to the phenotypic features of Akp2-/- mice, which recapitulate lethal infantile HPP extremely well, including bone abnormalities and vitamin B6-responsive seizures, with untreated seizing animals dying before weaning [43,44,45]. This evidence concerns the gene ALPL and hypophosphatasia.