Consistently, MIA-602 and MIA-690 have been reported to suppress STAT3 activity in SCLC and NSCLC cell lines in vitro [15] and in pleural mesothelioma in vivo [22] by inhibiting NF-κB, COX-2, and MMPs, both alone and in combination with chemotherapy drugs. The gene discussed is PTGS2; the disease is pleural mesothelioma.