Song et al. used pentylenetetrazol (PTZ) kindling to induce a temporal lobe epilepsy model, injecting recombinant RGMa protein and FAK inhibitor 14 intracerebroventricularly, reporting reduced FAK phosphorylation at Tyr397, seizure-suppressant effects, and RGMa-inhibited mossy fiber sprouting [31]. This evidence concerns the gene PTK2 and temporal lobe epilepsy.